Proteostasis RNA Metabolism
Gene co-expression module in Neutrophils
| Category | Housekeeping |
|---|---|
| Genes | 9 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include PSMB7 (proteasome beta subunit 7, involved in protein degradation), HNRNPD (AU-rich element RNA-binding protein, post-transcriptional regulation), APP (amyloid precursor protein, involved in vesicular transport and membrane homeostasis), TMEM87A (transmembrane protein, Golgi/ER morphology), STT3B (oligosaccharyltransferase catalytic subunit, N-glycosylation in ER), SLC44A1 (choline transporter), MTDH (metadherin, stress response/RNA metabolism), RIF1 (DNA replication timing, telomere maintenance), SRSF11 (serine/arginine splicing factor). The combination of proteasomal degradation (PSMB7), RNA processing (HNRNPD, SRSF11, MTDH), ER glycosylation (STT3B), and DNA replication (RIF1) does not resolve to a tight single pathway. However, the dominant theme across hub genes is post-transcriptional/proteostatic housekeeping — a general cellular maintenance program common to many cell types. These genes collectively reflect baseline protein quality control and RNA metabolism.
Genes
APP, HNRNPD, MTDH, PSMB7, RIF1, SLC44A1, SRSF11, STT3B, TMEM87A
Most correlated modules
- Myeloid Maturation · correlation 0.91
- S-G2-M Cell Cycle · correlation 0.91
- Myeloid Lipid Remodeling · correlation 0.91
- mRNA Splicing Processing · correlation 0.89
- Endocytic Vesicular Trafficking · correlation 0.87
- General Homeostatic Regulation · correlation 0.84
- Mitotic Spindle · correlation 0.80
- Primary Granule Antimicrobial · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.