Neutrophil Differentiation
Gene co-expression module in Neutrophils
| Category | Developmental |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
ZBTB20 and DACH1 are developmental transcription factors with roles in cell fate specification. PLCL2 modulates phospholipase C signaling. DGKD (diacylglycerol kinase delta) attenuates DAG-mediated signaling. PTBP2 is an RNA-binding protein regulating alternative splicing during differentiation. MSRA is a methionine sulfoxide reductase involved in redox homeostasis. PAM is involved in neuropeptide processing. MPP7 is a MAGUK scaffold. Low expression and low detection rate, with TF-dominated composition, suggests a module reflecting a less-common neutrophil differentiation/developmental substate.
Genes
DACH1, DGKD, FAR1, MPP7, MSRA, PAM, PLCL2, PTBP2, RELL1, ZBTB20
Most correlated modules
- Granulopoiesis Program · correlation 0.94
- Apoptotic Neutrophil Program · correlation 0.92
- JAK-MAPK Signaling · correlation 0.91
- General Homeostatic Regulation · correlation 0.89
- ELMO-DOCK Chemotaxis · correlation 0.89
- Degranulation Trafficking · correlation 0.87
- NET Priming State · correlation 0.83
- Signal Attenuation · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.