Glycolytic Metabolism
Gene co-expression module in Neutrophils
| Category | Housekeeping |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 13 genes have a known function matching the annotation |
Why this annotation
The top hub genes TPI1, LDHA, GAPDH, and ENO1 are canonical glycolytic enzymes, anchoring this module in glucose metabolism. Supporting genes include CTSD (lysosomal cathepsin D), CSTB (lysosomal protease inhibitor), GRN (granulin, lysosomal), MIF (glycolysis-linked cytokine), PLIN2 (lipid droplet/metabolic), GSTO1 (oxidative stress metabolism), TPT1 (metabolic growth regulator), and FAM210A (mitochondrial). This co-expression of glycolysis and lysosomal metabolic genes is consistent with the aerobic glycolysis program of mature/activated neutrophils. Uniform expression supports a constitutive metabolic housekeeping role. Neighbor M16's translational program complements this metabolic module.
Genes
CSTB, CTSD, ENO1, FAM210A, GAPDH, GRN, GSTO1, LDHA, LGALS3, MIF, PLIN2, TPI1, TPT1
Most correlated modules
- Translational Housekeeping · correlation 0.52
- Translation Initiation · correlation 0.43
- CC Chemokine Secretion · correlation 0.37
- RNA Splicing · correlation 0.30
- Chemokine Secretion · correlation 0.25
- Mitotic Spindle · correlation 0.23
- Primary Granule Antimicrobial · correlation 0.21
- Heat Shock Response · correlation 0.21
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.