Mature Neutrophil Identity
Gene co-expression module in Neutrophils
| Category | Developmental |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
ALPL (alkaline phosphatase/TNAP) is a well-established surface marker of mature neutrophils, particularly band and segmented forms, used clinically in the leukocyte alkaline phosphatase (LAP) score to assess neutrophil maturity and activation. CR1 (CD35, complement receptor 1) is expressed on mature neutrophils and mediates complement-opsonized particle recognition. CRISPLD2 is a secreted LPS-binding protein with anti-inflammatory properties expressed by mature neutrophils. ST3GAL4 is a sialyltransferase modifying surface glycoproteins to regulate selectin-mediated rolling. PXN (paxillin) is a focal adhesion scaffold. IL4R expression on neutrophils marks an alternatively activated state. NIBAN1 is induced by ER stress. SH3GLB1 is an endophilin involved in membrane dynamics. The ALPL+CR1+CRISPLD2 core strongly identifies mature neutrophil surface identity.
Genes
ALPL, CR1, CRISPLD2, IL4R, NIBAN1, PXN, SH3GLB1, ST3GAL4
Most correlated modules
- PI3K Migration Signaling · correlation 0.96
- TLR5 Bacterial Sensing · correlation 0.94
- Endocytic Vesicle Trafficking · correlation 0.94
- Granulopoiesis Transcriptional · correlation 0.94
- Endosomal Vesicle Trafficking · correlation 0.92
- Mature Neutrophil Identity · correlation 0.92
- ER Stress Response · correlation 0.91
- Endosomal Vesicle Trafficking · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.