Myeloid Lipid Remodeling
Gene co-expression module in Neutrophils
| Category | Developmental |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes: ERG (ETS transcription factor critical for hematopoiesis/myeloid development), PDE4D (phosphodiesterase 4D, cAMP signaling regulator), CLTCL1 (clathrin heavy chain-like, endocytic trafficking), GPD2 (mitochondrial glycerol-3-phosphate dehydrogenase, metabolic), ADK (adenosine kinase, purine metabolism), AGPS (alkylglycerone phosphate synthase, ether lipid synthesis), HNRNPLL (RNA-binding protein), SLC39A11 (zinc transporter), TCF12 (E-protein transcription factor, lymphoid/myeloid development), ATP8A1 and ATP8B4 (P4-ATPases, lipid flippases), DOP1B (membrane trafficking). ERG and TCF12 are transcription factors involved in hematopoietic/myeloid development. The module contains lipid metabolism genes (AGPS, ATP8A1, ATP8B4 — phospholipid asymmetry/ether lipid synthesis), purine metabolism (ADK), cAMP signaling (PDE4D), and membrane/vesicular trafficking (CLTCL1, DOP1B). The transcription factor and lipid synthesis combination may reflect a neutrophil maturation/developmental state with active membrane lipid remodeling.
Genes
ADK, AGPS, ATP8A1, ATP8B4, CLTCL1, DOP1B, ERG, GPD2, HNRNPLL, PDE4D, SLC39A11, TCF12
Most correlated modules
- General Homeostatic Regulation · correlation 0.95
- Myeloid Maturation · correlation 0.95
- Endocytic Vesicular Trafficking · correlation 0.93
- Proteostasis RNA Metabolism · correlation 0.91
- Apoptotic Neutrophil Program · correlation 0.86
- S-G2-M Cell Cycle · correlation 0.84
- mRNA Splicing Processing · correlation 0.81
- Neutrophil Differentiation · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.