Degranulation Trafficking
Gene co-expression module in Neutrophils
| Category | Degranulation |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
RAB27A is a Rab GTPase critical for secretory vesicle docking and neutrophil degranulation (azurophilic and specific granule exocytosis). RIN3 is a Rab effector/GEF involved in endosomal trafficking. BIN2 regulates membrane tubulation relevant to vesicular trafficking. SYNE1/SYNE2 (nesprins) position the nucleus during polarized secretion. STK38 phosphorylates RAB27A effectors. PYGL provides metabolic support for degranulation. Together this module captures the secretory/degranulation vesicle trafficking program in neutrophils.
Genes
ATP11A, BIN2, CSGALNACT2, FRY, KDM7A, LPGAT1, PYGL, RAB27A, RIN3, RTN3, STK38, SYNE1, SYNE2, TCP11L2, WLS, ZNF106
Most correlated modules
- Signal Attenuation · correlation 0.94
- JAK-MAPK Signaling · correlation 0.94
- ELMO-DOCK Chemotaxis · correlation 0.90
- Actin Cytoskeletal Remodeling · correlation 0.90
- Stress Kinase Signaling · correlation 0.89
- Ubiquitin-Proteasome Turnover · correlation 0.88
- Cytoskeletal Remodeling · correlation 0.87
- Neutrophil Differentiation · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.