Myeloid Maturation
Gene co-expression module in Neutrophils
| Category | Developmental |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include LRMDA (myeloid differentiation receptor), CERS6 (ceramide synthase involved in lipid signaling/apoptosis), FAF1 (FAS-associated factor, apoptosis), DGKG (diacylglycerol kinase, signal transduction), PKP4 (cell junction), MSRB3 (methionine sulfoxide reductase, oxidative stress repair). The module is uniformly low-expressed and lacks a dominant neutrophil effector signature. The combination of lipid metabolism, apoptotic signaling, and myeloid-associated genes suggests a myeloid maturation or lineage-commitment program rather than a terminal effector program. Neighbor context (near proliferation and granule modules) supports a developmental interpretation.
Genes
AFF2, CERS6, DGKG, FAF1, LRMDA, MSRB3, PKP4, RSRC1
Most correlated modules
- Myeloid Lipid Remodeling · correlation 0.95
- Proteostasis RNA Metabolism · correlation 0.91
- S-G2-M Cell Cycle · correlation 0.91
- General Homeostatic Regulation · correlation 0.91
- Endocytic Vesicular Trafficking · correlation 0.82
- mRNA Splicing Processing · correlation 0.74
- Granulopoiesis Program · correlation 0.73
- Apoptotic Neutrophil Program · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.