NF-κB Activation
Gene co-expression module in Neutrophils
| Category | Inflammatory |
|---|---|
| Genes | 15 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes TNFAIP3 (A20), NFKBIA (IκBα), NFKB2, NFKBIZ, and TNIP1 are all canonical NF-κB pathway components or negative feedback regulators. TNFAIP6 is an anti-inflammatory mediator induced by NF-κB. PLAUR and PLEK are neutrophil activation markers. PPP1R15A (GADD34) and PLK3 add a stress-kinase/feedback dimension. The module is tightly core-coherent and uniformly expressed across neutrophil subsets, consistent with a pan-neutrophil NF-κB activation and attenuation program.
Genes
EHD1, GRAMD1A, NBN, NFKB2, NFKBIA, NFKBIZ, PLAUR, PLEK, PLK3, PPP1R15A, SLC15A3, TAGAP, TNFAIP3, TNFAIP6, TNIP1
Most correlated modules
- Neutrophil Adhesion Signaling · correlation 0.87
- Inflammasome IL-1 Response · correlation 0.83
- NF-κB Inflammatory Transcription · correlation 0.79
- Inflammatory Resolution · correlation 0.77
- Myeloid Inflammatory Activation · correlation 0.73
- Immediate Early Response · correlation 0.70
- NF-κB Signaling · correlation 0.70
- C5aR Complement Activation · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.