General Homeostatic Regulation
Gene co-expression module in Neutrophils
| Category | Housekeeping |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
The near-identical PageRank values across all genes suggest a loosely co-expressed rather than hub-driven module. MCU (mitochondrial calcium uniporter — mitochondrial calcium homeostasis), EXOC4 (exocyst complex, vesicle docking), MGAT5 (Golgi glycosyltransferase, N-glycan branching), ARID2 (SWI/SNF chromatin remodeling complex), RAD51B (homologous recombination DNA repair), FBXL17 (SCF E3 ubiquitin ligase), RASA1 (RAS GTPase-activating protein), LARP4B (RNA-binding, mRNA stability). These genes span mitochondria, DNA repair, glycosylation, and chromatin remodeling — a broad housekeeping/regulatory module without a tight effector identity. The uniform low-amplitude PageRank distribution and diverse functions suggest this may represent a general homeostatic program active in resting neutrophils.
Genes
ARID2, EXOC4, FBXL17, LARP4B, MCU, MGAT5, RAD51B, RASA1
Most correlated modules
- Myeloid Lipid Remodeling · correlation 0.95
- Myeloid Maturation · correlation 0.91
- Apoptotic Neutrophil Program · correlation 0.91
- Granulopoiesis Program · correlation 0.90
- Endocytic Vesicular Trafficking · correlation 0.90
- Neutrophil Differentiation · correlation 0.89
- Proteostasis RNA Metabolism · correlation 0.84
- S-G2-M Cell Cycle · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.