Translation Initiation
Gene co-expression module in Neutrophils
| Category | Housekeeping |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include HNRNPA1 (RNA-binding/splicing), NAP1L1 (nucleosome assembly protein), EIF1AX and EIF3A (translation initiation factors), NCL/nucleolin (rRNA processing, ribosome biogenesis), PTMA/prothymosin-alpha (chromatin remodeling, cell growth), PPIA/cyclophilin-A (housekeeping chaperone), SET (chromatin/PP2A inhibitor), RPN2 (dolichyl-diphosphooligosaccharide protein glycosyltransferase), VAMP8 (vesicle-associated membrane protein for granule fusion). This is a predominantly translational regulation and RNA metabolism housekeeping module, with a minor vesicle trafficking component (VAMP8). Neighbor to M12 (splicing factors), together they form a post-transcriptional gene expression neighborhood.
Genes
EIF1AX, EIF3A, HNRNPA1, NAP1L1, NCL, PPIA, PTMA, RPN2, SET, VAMP8
Most correlated modules
- Translational Housekeeping · correlation 0.90
- Primary Granule Antimicrobial · correlation 0.87
- Mitotic Spindle · correlation 0.85
- Proteostasis RNA Metabolism · correlation 0.74
- RNA Splicing · correlation 0.74
- S-G2-M Cell Cycle · correlation 0.65
- Immature Neutrophil Granule · correlation 0.64
- mRNA Splicing Processing · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.