Ubiquitin-Proteasome Regulation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 6 of 30 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression across subsets, with unknown coherence. The gene list includes FBXO22 (F-box ubiquitin ligase), TRIM73/TRIM52 (TRIM family E3 ligases), ZRANB2 (RNA-binding/splicing), ZNF26/ZNF888 (zinc finger transcription factors), MIS18BP1 (centromere/epigenetic), ARGLU1 (transcriptional coactivator), ATXN7L3B (histone deubiquitination complex), UTP14C (ribosome biogenesis), ZFC3H1 (RNA surveillance), NBR1 (autophagy receptor), PIAS2 (SUMO E3 ligase). This is a heterogeneous collection of housekeeping regulators spanning ubiquitin-proteasome, RNA processing, and transcriptional regulation with no coherent single program. The uniform expression and weak membership across all genes suggest a poorly defined, low-coherence module capturing background housekeeping co-variation. Neighbor context (M59, M10, M130, M96) all share the same weak/uniform pattern, reinforcing that this batch represents loosely co-expressed housekeeping genes.
Genes
Most correlated modules
- ER Quality Control · correlation 0.91
- DNA Repair & Chromatin · correlation 0.87
- Genome Organization · correlation 0.86
- Transcriptional Regulation · correlation 0.85
- Chromatin Remodeling · correlation 0.84
- Endosomal Trafficking · correlation 0.83
- Lipid Transport & Membrane · correlation 0.82
- IFN Receptor Signaling · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.