Lipid Metabolic Reprogramming
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
AOAH (acyloxyacyl hydrolase, LPS detoxification), LPCAT2 (lysophosphatidylcholine acyltransferase, phospholipid remodeling), PLAAT4 (phospholipase A/acyltransferase), FASN (fatty acid synthase), and CEBPD (inflammatory C/EBP TF) collectively point to a lipid metabolism and phospholipid remodeling program. FGR (Src-family kinase), ITGAX (CD11c, DC marker), and CD33 (myeloid marker) add myeloid identity context. This module likely reflects lipid metabolic reprogramming in activated myeloid/DC states.
Genes
Most correlated modules
- Innate Myeloid Effector · correlation 0.77
- Myeloid Differentiation · correlation 0.75
- Inflammatory Activation · correlation 0.67
- Glycolytic Metabolism · correlation 0.61
- Mixed Signaling Regulation · correlation 0.61
- IFN-Vesicular Response · correlation 0.58
- Kinase Phosphatase Signaling · correlation 0.55
- Survival & Adhesion · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.