Stress & Apoptotic Priming
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 32 genes have a known function matching the annotation |
Why this annotation
PER1 and NFIL3 are core circadian clock components. ZFP36L1 regulates mRNA stability under stress. SGK1 is a stress-activated kinase. DDIT3 (CHOP) and PMAIP1 (NOXA) are ER stress and apoptotic priming markers. KLF2 maintains quiescence. TGIF1 is a TGF-beta signaling repressor. RHOB and RHOH are Rho GTPases involved in cytoskeletal stress responses. TUBA4A and TUBB4B are tubulin subunits. IFITM3 is an antiviral ISG. SLC2A3 is a stress-induced glucose transporter. DDIT3 and PMAIP1 together with SGK1 suggest a stress/apoptotic priming state. The module is weakly coherent and mixes circadian, stress, and cytoskeletal programs, but stress response is the dominant theme given neighbor M83 (dissociation stress).
Genes
Most correlated modules
- Glucocorticoid Stress Response · correlation 0.88
- Autophagy Cytoskeletal · correlation 0.82
- pDC Activation Response · correlation 0.80
- Chemokine Migration Response · correlation 0.80
- Heat Shock Response · correlation 0.78
- Post-transcriptional Regulation · correlation 0.73
- Inflammatory Activation · correlation 0.73
- Survival & Adhesion · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.