Mitochondrial Ribosome
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 26 genes have a known function matching the annotation |
Why this annotation
This module contains multiple mitochondrial ribosomal proteins (MRPL51, MRPL57, MRPS18C, MRPL20), Complex I subunits (NDUFAB1, NDUFS8, NDUFS7), and general housekeeping genes (DAD1, PSMA7, LSM6, TRMT112). All genes show uniform expression and weak membership, consistent with a loosely co-regulated housekeeping/mitochondrial program. The mitochondrial ribosome proteins are the most coherent sub-theme, supporting a mitochondrial translation label. Neighbor modules confirm the mitochondrial OxPhos neighborhood context.
Genes
Most correlated modules
- Respiratory Chain · correlation 0.91
- Complex I Subunits · correlation 0.89
- Mitochondrial Assembly · correlation 0.88
- Lysosomal mTOR Signaling · correlation 0.86
- Complex I Assembly · correlation 0.86
- Clathrin-mediated Endocytosis · correlation 0.85
- Actin Cytoskeleton · correlation 0.84
- General Housekeeping · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.