Glucocorticoid Stress Response
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include TSC22D3 (GILZ, glucocorticoid-induced leucine zipper, a canonical glucocorticoid response gene), DDIT4 (REDD1, stress-induced mTOR inhibitor, also glucocorticoid-responsive), SAT1 (spermidine/spermine acetyltransferase, stress/polyamine catabolism), WSB1 (SOCS box protein, hypoxia/ubiquitin), GLUL (glutamine synthetase, metabolic stress), BRD2 (bromodomain chromatin reader), NLRC5 (MHC-I transactivator). TSC22D3 and DDIT4 together are a strong signature of glucocorticoid/stress response. Despite weak membership, this is the most coherent biological signal in the batch.
Genes
Most correlated modules
- Stress & Apoptotic Priming · correlation 0.88
- Autophagy Cytoskeletal · correlation 0.83
- Transcriptional Regulation · correlation 0.77
- IFN-Vesicular Response · correlation 0.76
- TGF-beta Survival · correlation 0.76
- Chemokine Migration Response · correlation 0.76
- Transcriptional Repression · correlation 0.75
- Transcription Regulation · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.