Mixed Signaling
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 3 of 9 genes have a known function matching the annotation |
Why this annotation
This small 9-gene module has unknown coherence and all weak memberships. CFAP251 is a cilia/flagella-associated protein. IGFBP2 is an IGF-binding protein involved in growth regulation. PANX1 is a pannexin channel involved in purinergic signaling and apoptotic signaling. S100A1 is a calcium-binding protein. MAGI3 is a scaffold/PDZ protein. PRDM8 is a transcriptional repressor. The module is highly heterogeneous with no clear unifying program. CFAP251 and PANX1 could link to cell death/stress signaling but the evidence is weak. Classified as poorly defined housekeeping given the lack of coherence.
Genes
Most correlated modules
- Mitotic Cell Cycle · correlation 0.86
- Hematopoietic Development · correlation 0.82
- Survival & Adhesion · correlation 0.77
- Antiviral Innate Sensing · correlation 0.64
- Cell Cycle Regulation · correlation 0.63
- Progenitor Transcription · correlation 0.54
- Glycolytic Metabolism · correlation 0.39
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.