Progenitor Transcription
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Development |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 24 genes have a known function matching the annotation |
Why this annotation
Top hub genes HOXA10 and HOXA9 are HOX transcription factors critical for hematopoietic stem/progenitor identity and myeloid differentiation. CLEC11A is a hematopoietic growth factor (stem cell factor). IGF2BP3 is an RNA-binding protein marking immature/progenitor cells. GAS7 promotes differentiation. CD79B is a B cell receptor component suggesting lymphoid progenitor context. MYC drives proliferation in progenitors. This module likely reflects a hematopoietic progenitor or immature DC transcriptional program. All genes are weakly defined but the HOX gene anchor is informative.
Genes
Most correlated modules
- Hematopoietic Development · correlation 0.84
- Glycolytic Metabolism · correlation 0.83
- Survival & Adhesion · correlation 0.77
- Myeloid Differentiation · correlation 0.68
- Post-transcriptional Regulation · correlation 0.66
- Lymphomyeloid Progenitor · correlation 0.56
- Mixed Signaling · correlation 0.54
- Lipid Metabolic Reprogramming · correlation 0.46
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.