Antiviral Innate Sensing
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Antiviral |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 2 of 22 genes have a known function matching the annotation |
Why this annotation
MAVS (mitochondrial antiviral signaling protein) is the top hub — a central adaptor for RIG-I/MDA5 innate antiviral sensing that activates IRF3/NF-kB. SMAD4 (TGF-beta canonical signaling), MACF1 (cytoskeletal scaffold), DYNC1LI2 (dynein light intermediate chain, involved in viral trafficking), CEP97 (centrosome), CLPB (mitochondrial disaggregase), ZFYVE16 (endosomal signaling). MAVS as the dominant hub in pDCs — the premier antiviral innate immune cell type — suggests a basal antiviral/innate sensing program, though weak membership limits confidence. Neighbor context (STAT3/STAT6 in M74) supports an innate immune signaling neighborhood.
Genes
Most correlated modules
- Chromatin Remodeling · correlation 0.79
- pDC Identity & Splicing · correlation 0.77
- RNA Processing Regulation · correlation 0.74
- Genome Organization · correlation 0.71
- RNA Splicing Regulation · correlation 0.71
- JAK-STAT Signaling · correlation 0.69
- Mixed Signaling · correlation 0.64
- Cell Cycle Regulation · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.