Metabolic Stress Response
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 6 of 24 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. Hub gene FPGS (folylpolyglutamate synthase, folate metabolism) is notable. PPM1D (WIP1 phosphatase, attenuates DNA damage response), SLC7A11 (xCT cystine/glutamate transporter, oxidative stress defense/ferroptosis resistance), TFE3 (transcription factor, lysosomal biogenesis/stress response), ABCC1 (multidrug resistance transporter), and ISCA1 (iron-sulfur cluster assembly, mitochondrial) suggest a loose stress/metabolic adaptation theme. SNX9 and IGF2R relate to endosomal sorting. The module is heterogeneous with no single tight program.
Genes
Most correlated modules
- Rho GEF Migration · correlation 0.88
- Mixed Regulatory · correlation 0.84
- NF-κB Immune Signaling · correlation 0.75
- RNA Processing · correlation 0.73
- Cell Cycle Regulation · correlation 0.72
- Epigenetic Regulation · correlation 0.72
- Epigenetic Regulation · correlation 0.69
- Transcription Regulation · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.