IFN-Vesicular Response
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Antiviral |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 24 genes have a known function matching the annotation |
Why this annotation
GBP2 is a prominent interferon-stimulated GTPase; IFI30 encodes GILT, an IFN-gamma-induced lysosomal thiol reductase involved in antigen processing; STX11 and RAB27A are vesicle trafficking components relevant to cytotoxic/secretory granule release. FOXM1 and H2BC7 suggest a proliferative sub-signal. SRSF2/SRSF3 are splicing regulators. The module is mixed but the IFN-response and vesicular trafficking genes are the strongest biological thread, consistent with pDC activation states.
Genes
Most correlated modules
- Epigenetic Regulation · correlation 0.79
- Glucocorticoid Stress Response · correlation 0.76
- Inflammatory Activation · correlation 0.72
- Myeloid Differentiation · correlation 0.71
- Stress & Apoptotic Priming · correlation 0.68
- Survival & Adhesion · correlation 0.67
- Post-transcriptional Regulation · correlation 0.63
- Cell Cycle Regulation · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.