Innate Myeloid Effector
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 16 genes have a known function matching the annotation |
Why this annotation
P2RY13 (purinergic receptor on myeloid cells), SCIMP (TLR signaling scaffold on myeloid cells), PSTPIP2 (inflammatory arthritis-associated, innate immune regulator), LYZ (lysozyme, innate effector), TBXAS1 (thromboxane synthase, inflammatory lipid mediator), FGL2 (fibrinogen-like immunosuppressive protein), LGALS2 (galectin-2, innate immune modulator), S100B (alarmin/DAMP), PLBD1 (lysosomal enzyme, myeloid). This module reflects innate myeloid effector functions including pattern recognition, inflammatory lipid production, and alarmin signaling.
Genes
Most correlated modules
- Myeloid Differentiation · correlation 0.84
- Lipid Metabolic Reprogramming · correlation 0.77
- Inflammatory Activation · correlation 0.74
- IFN-Vesicular Response · correlation 0.59
- Glycolytic Metabolism · correlation 0.56
- CX3CR1 Migration · correlation 0.48
- Lymphomyeloid Progenitor · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.