CX3CR1 Migration
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 9 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence, but this module has the most interpretable composition in the batch. CX3CR1 (fractalkine receptor, expressed on tissue-resident and migratory immune cells including pDC subsets) is the top hub gene. CTNND1 (p120-catenin, adherens junction/cell-cell adhesion), CDC42BPB (MRCKB, cytoskeletal kinase downstream of CDC42), DOCK5 (Rac1 GEF, cytoskeletal remodeling/migration), RAB32 (vesicle trafficking/phagosome maturation), HEATR5A (clathrin-related), CENPN (centromere). CX3CR1 is a known marker of non-classical monocytes and certain tissue-resident pDC populations. The combination of CX3CR1 with cytoskeletal/adhesion genes (CTNND1, CDC42BPB, DOCK5) suggests a migration/tissue residency program, though weak membership of all genes limits confidence. This module is the most biologically distinct neighbor in the batch.
Genes
Most correlated modules
- Mixed Housekeeping · correlation 0.82
- Mixed Housekeeping · correlation 0.77
- Chromatin Regulation · correlation 0.76
- TLR Signaling Regulation · correlation 0.75
- Epigenetic Regulation · correlation 0.72
- Mixed Housekeeping · correlation 0.69
- Cilia & Centrosome · correlation 0.60
- Innate Myeloid Effector · correlation 0.48
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.