Inflammatory Activation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 18 genes have a known function matching the annotation |
Why this annotation
CXCL8 (IL-8) is a prototypical inflammatory chemokine; TNFAIP2 is TNF-alpha-induced; LGALS3 (galectin-3) promotes inflammatory signaling; ADAM8 is a metalloprotease upregulated in inflammation; MARCKS is a PKC substrate involved in inflammatory cell activation; WARS1 (tryptophanyl-tRNA synthetase) is IFN-induced; HAVCR2 (TIM-3) marks activated/exhausted immune cells; PRDM1 (BLIMP1) drives terminal differentiation of immune cells. Together these genes reflect an inflammatory activation and terminal differentiation state.
Genes
Most correlated modules
- Innate Myeloid Effector · correlation 0.74
- Stress & Apoptotic Priming · correlation 0.73
- Myeloid Differentiation · correlation 0.73
- IFN-Vesicular Response · correlation 0.72
- Lipid Metabolic Reprogramming · correlation 0.67
- DC Maturation Migration · correlation 0.62
- Post-transcriptional Regulation · correlation 0.57
- Glycolytic Metabolism · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.