Complex I Assembly
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 11 genes have a known function matching the annotation |
Why this annotation
Small 11-gene module with weak coherence. NDUFA8 and NDUFC1 are NADH dehydrogenase (Complex I) subunits; MRPL27 is a mitochondrial ribosomal protein; MTLN (mitoregulin) regulates mitochondrial function. PSENEN is a presenilin enhancer involved in gamma-secretase. HCST (DAP10) is an immune signaling adaptor. NAA38, RNF181, A1BG, POLR2I, POP4 are general housekeeping. The module is a weak, mixed housekeeping cluster with a minor mitochondrial thread, consistent with the broader neighborhood.
Genes
Most correlated modules
- Respiratory Chain · correlation 0.88
- Mitochondrial Ribosome · correlation 0.86
- Mitochondrial Import · correlation 0.83
- Actin Cytoskeleton · correlation 0.81
- Complex I Subunits · correlation 0.81
- Fc Receptor Trafficking · correlation 0.80
- ATP Synthase Complex · correlation 0.74
- M18 · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.