Actin Cytoskeleton
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes CAP1, ACTR3, ARPC2, CAPZA2, and CDC42 all function in actin cytoskeleton dynamics (Arp2/3 complex, actin capping, Rho GTPase signaling). BUB3 adds a spindle checkpoint component. Peripheral genes (MRPS10, SDHAF3, COPB2, YBX1) are housekeeping. All genes show weak membership and uniform expression, indicating a loosely coherent module anchored on actin regulation. Neighbor M101 shares vesicular trafficking genes (COPB2/COPI overlap with TMED10), consistent with cytoskeletal-trafficking co-regulation.
Genes
Most correlated modules
- Clathrin-mediated Endocytosis · correlation 0.91
- Metabolic Housekeeping · correlation 0.89
- Lysosomal mTOR Signaling · correlation 0.86
- ER-Golgi Trafficking · correlation 0.85
- General Cellular Maintenance · correlation 0.85
- ER Protein Folding · correlation 0.84
- Ubiquitin Proteasome · correlation 0.84
- Cell Cycle Regulation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.