Vesicular Immune Signaling
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 6 of 15 genes have a known function matching the annotation |
Why this annotation
PDCD6IP (ALIX/ESCRT-III accessory protein, exosome biogenesis), GOLGA5 (Golgi apparatus structural protein), RAP1B (small GTPase, vesicle trafficking/integrin signaling), KIF2A (kinesin motor, microtubule depolymerization), IRAK4 (TLR/IL-1R signaling kinase critical in pDCs), ERAP1 (ER aminopeptidase, antigen processing), and multiple ZNF transcription factors. The module loosely combines vesicular/Golgi trafficking with innate immune signaling. IRAK4 and ERAP1 are particularly relevant to pDC TLR7/9 signaling and antigen presentation. Weak coherence limits interpretation.
Genes
Most correlated modules
- Metabolic Housekeeping · correlation 0.89
- M18 · correlation 0.87
- Centrosome DNA Damage · correlation 0.86
- DNA Repair Housekeeping · correlation 0.83
- Chromatin RNA Regulation · correlation 0.83
- pDC Identity Signaling · correlation 0.82
- Ubiquitin Proteasome · correlation 0.81
- Endosomal Trafficking · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.