Chromatin RNA Regulation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 8 of 26 genes have a known function matching the annotation |
Why this annotation
SMARCA5 (ISWI chromatin remodeling ATPase), ETAA1 (ATR kinase activator, DNA replication stress response), CEP135 (centrosome/centriole assembly), TSC1 (tuberous sclerosis complex, mTOR regulation), CAPRIN1 (stress granule assembly, RNA binding), ADAT1 (adenosine deaminase acting on tRNA), TRMT13 (tRNA methyltransferase), APOOL (MINOS complex, mitochondrial inner membrane). The module combines chromatin remodeling, DNA damage/replication stress, tRNA modification, and stress granule biology. The tRNA modification genes (ADAT1, TRMT13) and chromatin remodeler SMARCA5 suggest a loose RNA/chromatin regulatory housekeeping program.
Genes
Most correlated modules
- Centrosome DNA Damage · correlation 0.95
- Chromatin & Ubiquitin · correlation 0.88
- DNA Repair Housekeeping · correlation 0.86
- Vesicular Immune Signaling · correlation 0.83
- Actin Cytoskeleton · correlation 0.78
- pDC Identity & Splicing · correlation 0.77
- Chromatin Regulation · correlation 0.75
- RNA Processing · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.