DNA Repair Housekeeping
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence, indicating a poorly defined module. Hub genes include RFC1 (DNA replication clamp loader), MRE11 (DNA double-strand break repair), CASP8AP2 (apoptosis/transcription), TAF15 (RNA polymerase II transcription), NGLY1 (N-glycanase), and REST (transcriptional repressor). The module loosely combines DNA repair and general transcriptional/housekeeping functions without a tight biological program. Given the weak coherence and uniform expression, this likely reflects background co-variation of broadly expressed housekeeping genes.
Genes
Most correlated modules
- pDC Identity Signaling · correlation 0.90
- Chromatin & Ubiquitin · correlation 0.89
- Centrosome DNA Damage · correlation 0.87
- Centrosome Organization · correlation 0.87
- Chromatin RNA Regulation · correlation 0.86
- Chromatin Remodeling · correlation 0.85
- Actin Cytoskeleton · correlation 0.84
- Lipid Transport & Membrane · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.