pDC Identity Signaling
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Development |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 21 genes have a known function matching the annotation |
Why this annotation
Despite weak coherence, several genes point to lymphoid/pDC identity and signaling: BCL11A (key pDC transcription factor), LAIR1 (inhibitory receptor on pDCs), DOCK2 (Rho GEF critical for lymphocyte migration and pDC function), LYN (Src-family kinase in B/pDC signaling), SKAP2 (signaling adaptor in immune cells), IL18R1 (cytokine receptor), NPC1 (cholesterol/lipid trafficking). FMNL3 links to actin cytoskeleton. The module may reflect a pDC identity/signaling background program, but weak membership across all genes limits confidence.
Genes
Most correlated modules
- Immune Cell Migration · correlation 0.94
- DNA Repair Housekeeping · correlation 0.90
- Polycomb Transcription · correlation 0.86
- Centrosome Organization · correlation 0.85
- DNA Damage Response · correlation 0.85
- Actin Cytoskeleton · correlation 0.85
- Lipid Transport & Membrane · correlation 0.83
- Vesicular Immune Signaling · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.