Rho GEF Signaling
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 3 of 8 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. This is a very small module (8 genes). Hub genes include F2RL2 (protease-activated receptor 3, signaling), IPP (ICAP-1/integrin cytoplasmic domain-associated protein, actin/cytoskeletal), DOCK1 (dedicator of cytokinesis 1, Rac1 GEF, cell migration/phagocytosis), NUP133 (nuclear pore complex), USP25 (deubiquitinase), THAP9 (transposase-derived, DNA binding), CCDC77, and ZNF827. DOCK1 and IPP have cytoskeletal/migration roles; NUP133 is nuclear transport. The module is too small and heterogeneous to assign a confident label; DOCK1 and IPP suggest a loose cytoskeletal/migration theme.
Genes
Most correlated modules
- Cell Cycle Regulation · correlation 0.94
- Zinc Finger Transcription · correlation 0.93
- Rho GEF Migration · correlation 0.82
- ARF-mediated Trafficking · correlation 0.82
- Metabolic Stress Response · correlation 0.67
- Cell Cycle Regulation · correlation 0.61
- Epigenetic Regulation · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.