Cell Cycle Regulation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 4 of 34 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. Among the genes, MCM9 (minichromosome maintenance, DNA replication licensing), CDCA4 (cell division cycle associated, transcriptional repressor linked to cell cycle), CDK8 (cyclin-dependent kinase 8, cell cycle/transcription), and PFAS (phosphoribosylformylglycinamidine synthase, purine biosynthesis for proliferating cells) suggest a loose proliferation/cell cycle theme. However, ALG9 (N-glycosylation), ABCC4 (ABC transporter), and GPR39 (GPCR) are unrelated. The module is weakly defined and heterogeneous.
Genes
Most correlated modules
- Rho GEF Signaling · correlation 0.94
- Zinc Finger Transcription · correlation 0.89
- Rho GEF Migration · correlation 0.84
- ARF-mediated Trafficking · correlation 0.77
- Metabolic Stress Response · correlation 0.72
- Epigenetic Regulation · correlation 0.71
- Stress Kinase Signaling · correlation 0.67
- Cell Cycle Regulation · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.