TLR Signaling Regulation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 5 of 40 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. The module contains some immune-relevant genes: IRAK3 (negative regulator of TLR/IL-1 signaling), PELI1 (E3 ubiquitin ligase in TLR/NF-κB pathway), CD72 (B cell inhibitory receptor), SERINC5 (antiviral restriction factor), P2RX4 (purinergic receptor). Also contains cell cycle/DNA damage genes: CHEK1, UHRF1, H3C10, H2AC8 (histones). IRS2 (insulin signaling), SESN1 (stress/mTOR). The immune signaling genes (IRAK3, PELI1, CD72) hint at TLR pathway regulation relevant to pDCs, but the module is too heterogeneous and all memberships are weak to confidently assign a specific program. The histone genes suggest possible cell cycle contamination of the module.
Genes
Most correlated modules
- Epigenetic Regulation · correlation 0.81
- Mixed Housekeeping · correlation 0.80
- Mixed Housekeeping · correlation 0.79
- Mixed Housekeeping · correlation 0.77
- CX3CR1 Migration · correlation 0.75
- Chromatin Regulation · correlation 0.75
- Cilia & Centrosome · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.