Cilia & Centrosome
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 6 of 18 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. Notable genes include CEP83 (centriolar satellite/ciliogenesis), WDR19 (IFT complex/cilia), RTTN (cilia/centrosome), TAPT1 (transmembrane/cilia-associated), CRACR2A (calcium sensor/vesicle), GOLGA1 (Golgi), PTPRM (receptor tyrosine phosphatase), NEGR1 (cell adhesion), CDK19 (mediator kinase), MAP4K3 (MAPK pathway), LCLAT1 (lipid remodeling). There is a partial enrichment for cilia/centrosome-associated genes (CEP83, WDR19, RTTN, TAPT1), but the module is otherwise heterogeneous and all memberships are weak. Given the pDC context and the cilia-related genes, this may reflect a weak ciliogenesis/centrosome program, but the overall coherence is too low to be confident.
Genes
Most correlated modules
- Intracellular Kinase Signaling · correlation 0.90
- Low-coherence Background · correlation 0.88
- Low-coherence Background · correlation 0.86
- Mixed Housekeeping · correlation 0.85
- Low-coherence Background · correlation 0.83
- Low-coherence Background · correlation 0.83
- Low-coherence Background · correlation 0.78
- Low-coherence Background · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.