Mixed Housekeeping
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 5 of 17 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. Gene composition is heterogeneous: MRTFB (transcriptional coactivator of SRF, cytoskeletal gene regulation), NRF1 (mitochondrial biogenesis transcription factor), COG5 (Golgi tethering), SPIDR (DNA repair scaffold), NT5C2/ADK (nucleotide metabolism), PLCB4 (phospholipase signaling), NBEA (scaffolding protein), PPP3CC (calcineurin). Shares MRTFB with M166's MRTFA, and COG5 with M166's COG6, confirming topological proximity via shared housekeeping transcriptional programs. No specific biological program dominates.
Genes
Most correlated modules
- Mixed Housekeeping · correlation 0.93
- Chromatin Regulation · correlation 0.91
- Mixed Housekeeping · correlation 0.87
- Cilia & Centrosome · correlation 0.85
- Low-coherence Background · correlation 0.82
- TLR Signaling Regulation · correlation 0.77
- Low-coherence Background · correlation 0.76
- Low-coherence Background · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.