Mixed Housekeeping
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 5 of 18 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence, indicating a poorly defined module. The gene composition is highly heterogeneous: CCDC134 (cilia), UBE3D/KLHL13 (ubiquitin-proteasome), ST3GAL6/CRPPA (glycosylation), COG6 (Golgi), VPS50 (vesicle traficking), WRN/SHLD2 (DNA repair), CYTH3 (ARF GEF), MRTFA (transcriptional coactivator). No single coherent biological program is identifiable. The module likely represents background co-variation of lowly expressed housekeeping genes. Neighbor M167 shares MRTFB (paralog of MRTFA) and COG5 (paralog of COG6), confirming these are co-expression network neighbors driven by shared low-level housekeeping transcription rather than a specific program.
Genes
Most correlated modules
- Mixed Housekeeping · correlation 0.93
- Mixed Housekeeping · correlation 0.91
- Chromatin Regulation · correlation 0.90
- Epigenetic Regulation · correlation 0.87
- TLR Signaling Regulation · correlation 0.79
- Low-coherence Background · correlation 0.77
- CX3CR1 Migration · correlation 0.77
- Low-coherence Background · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.