Proteostasis Quality Control
Gene co-expression module in Pericytes
| Category | Housekeeping |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include DNAJB6 (HSP40 co-chaperone), HSPE1 (HSP10, mitochondrial chaperonin), HSP90AB1 (HSP90β), MAP1LC3B (autophagosome marker, LC3B), UBE2D3 (ubiquitin-conjugating enzyme), and GNAI3 (Gi protein). The module combines chaperone activity (DNAJB6, HSPE1, HSP90AB1) with autophagy (MAP1LC3B) and ubiquitin-proteasome pathway (UBE2D3), pointing to a proteostasis/protein quality control program. MRPL18 (mitochondrial ribosomal protein) and HNRNPF (RNA-binding protein) are peripheral members. This is a coherent proteostasis module distinct from the acute heat-shock response in M72 and M20, focusing on constitutive protein quality control via chaperone-autophagy-ubiquitin axis.
Genes
DNAJB6, GNAI3, HNRNPF, HSP90AB1, HSPE1, MAP1LC3B, MRPL18, UBE2D3
Most correlated modules
- RNA Splicing Processing · correlation 0.92
- NF-κB Inflammatory Response · correlation 0.88
- Proteotoxic Stress Response · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.