NF-κB Inflammatory Response
Gene co-expression module in Pericytes
| Category | Inflammatory |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include ICAM1 (adhesion molecule, NF-κB target), BCL3 (NF-κB co-activator), BHLHE40 (inflammatory transcription factor), FOSL2 (AP-1 component), TRIB1 (inflammatory signaling scaffold), TNFAIP2 (TNF-induced), PIM3 (cytokine-induced kinase), KLF10 (TGF-β/inflammatory TF), and ADAMTS9 (ECM protease). This is a coherent NF-κB/AP-1 inflammatory transcriptional response module. The significant up-regulation in remission (UC) and down in CD remission may reflect differential inflammatory resolution. Neighbor M20 (immediate-early AP-1 genes) and M54 (KLF2/KLF4 quiescence) provide context: M47 represents the sustained inflammatory transcriptional program downstream of the immediate-early response in M20.
Genes
ABL2, ADAMTS9, ARL4A, BCL3, BHLHE40, FOSL2, ICAM1, KLF10, PIM3, TNFAIP2, TRIB1, UPP1
Most correlated modules
- EMT-like Remodeling · correlation 0.92
- Proteostasis Quality Control · correlation 0.88
- Proteotoxic Stress Response · correlation 0.87
- RNA Splicing Processing · correlation 0.86
- Vascular Quiescence · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.