RNA Splicing Processing
Gene co-expression module in Pericytes
| Category | Housekeeping |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include PCBP1/PCBP2 (poly(rC)-binding RNA binding proteins), RBM8A (exon junction complex component), SRSF4 (serine/arginine-rich splicing factor), ENY2 (mRNA export/transcription elongation), and WAC (chromatin ubiquitination/splicing coupling). RTN4 (reticulon-4, ER shaping) and PLSCR1 (phospholipid scramblase) are somewhat divergent but may reflect co-regulation in ER-associated RNA processing. The dominant program is post-transcriptional RNA processing and splicing. Moderate coherence with PCBP2 and SRSF4 as weaker members is consistent with a mixed splicing/RNA-binding module.
Genes
ENY2, PCBP1, PCBP2, PLSCR1, RBM8A, RTN4, SLC3A2, SRSF4, WAC
Most correlated modules
- RAS Cytoskeletal Signaling · correlation 0.94
- mRNA Stability Regulation · correlation 0.93
- Type I Interferon · correlation 0.92
- Proteostasis Quality Control · correlation 0.92
- TGF-beta Negative Feedback · correlation 0.92
- G-protein Signaling Scaffold · correlation 0.92
- Golgi Vesicular Trafficking · correlation 0.89
- ER-Actin Cytoskeletal · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.