Proteotoxic Stress Response
Gene co-expression module in Pericytes
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include HSPH1 (HSP110 family chaperone), DNAJA4 (HSP40 co-chaperone), BAG3 (BAG-domain co-chaperone), and CDKN1A (p21, stress-induced cell cycle arrest). ZC3HAV1 is an antiviral/stress RNA sensor, SLC2A3 is a stress-induced glucose transporter, DUSP5 is a stress-responsive MAPK phosphatase, and HES1 is a Notch target. The module is dominated by proteotoxic/heat-shock stress response genes alongside CDKN1A-mediated growth arrest. The disease response pattern (down in inflammation, up in remission for UC) suggests this reflects a pericyte stress-recovery or quiescence program. Neighbor M20 contains canonical immediate-early genes and HSPs, supporting a shared stress-response neighborhood. The combination of chaperones + CDKN1A + DUSP5 points specifically to proteotoxic stress with growth arrest.
Genes
BAG3, CDKN1A, DDX3X, DNAJA4, DUSP5, HES1, HSPH1, SLC2A3, TRA2B, ZC3HAV1
Most correlated modules
- Vascular Quiescence · correlation 0.90
- NF-κB Inflammatory Response · correlation 0.87
- EMT-like Remodeling · correlation 0.87
- Immediate Early Gene · correlation 0.86
- Proteostasis Quality Control · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.