SCUBA

HNRNPF — Heterogeneous nuclear ribonucleoprotein F

HNRNPF belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

HNRNPF's module in each cell type

Cell typeModuleShares the module with
CD8⁺ T cellsHistone Synthesis S-phase
Cell cycle
CDK2, EIF4EBP1, HAT1, HPRT1, PAQR4, RMI2, SLBP, TMEM109View in SCUBA
EndothelialStress RNA Processing
RNA processing & translation
ARF4, CACYBP, ELOC, ENY2, EWSR1, GNA14, HNRNPDL, MAP3K13 +5 moreView in SCUBA
Gamma-delta T cellsmRNA Splicing
RNA processing & translation
ACTB, ACTG1, ACTL6A, ACTR3, AK2, BRD8, CASP2, CCDC14 +13 more
Glial cellsOxidative Stress Response
Stress
CAP1, CD59, CXXC5, EEF2, ENO1, KLF9, NDUFA11, NFE2L2 +3 moreView in SCUBA
Hematopoietic progenitor cellsProteostasis & OxPhos
Mitochondrial & OxPhos
COX5A, EIF5A, HSPA8, ILF2, MRPS34, NDUFB6, PSMB5, SLBP
Innate lymphoid cellsDNA Damage Response
Stress
ANP32E, CCT6A, CLTB, FGFR1OP2, GNL3, JPT1, MRPS6, PDCD10 +7 moreView in SCUBA
Lymphatic endothelialNRF2 Oxidative Stress
Stress
B4GALT1, CTTNBP2NL, DDX21, DRAM1, GCH1, MSN, NFE2L2, PDXDC1 +11 moreView in SCUBA
MacrophagesRNA Processing & Repair
Housekeeping
BRD7, CCDC59, CCT4, CCT6A, CNDP2, EIF3J, EIF5B, EMC4 +31 moreView in SCUBA
Mucosal-associated invariant T cellActin Cytoskeletal Remodeling
Cytoskeletal
ANXA6, CAP1, CASP1, CCT5, CCT6A, DEF6, FGD3, GIMAP6 +7 more
Natural Killer cellsOxidative Stress Response
Stress
BANF1, CCDC167, CCT6A, CHCHD2, HINT1, HMGN1, NPM1, PA2G4 +2 moreView in SCUBA
PericytesProteostasis Quality Control
Housekeeping
DNAJB6, GNAI3, HSP90AB1, HSPE1, MAP1LC3B, MRPL18, UBE2D3View in SCUBA
Smooth muscle cellshnRNP & Proteasome
RNA processing & translation
ARF1, CCT2, GDI2, HNRNPA2B1, HNRNPA3, HNRNPU, PSMD8, PSMG2 +2 moreView in SCUBA

About the gene

SynonymsHNRPF
Chromosome10: 43385617-43409186
Predicted locationIntracellular
Essential geneNo
Protein classPlasma proteins, Predicted intracellular proteins
Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Function

Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.