MRPL18 — Mitochondrial ribosomal protein L18

MRPL18 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MRPL18's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Heat Shock Response Stress	BAG3, CHORDC1, DDIT4, DEDD2, DNAJA4, DNAJB1, DNAJB4, DNAJB6 +13 more	View in SCUBA
CD4⁺ T cells	Heat Shock Response Stress	ANKRD37, CHORDC1, DEDD2, DNAJA1, DNAJA4, DNAJB1, DNAJB4, HSP90AA1 +12 more	View in SCUBA
CD8⁺ T cells	Heat Shock Response Stress	AHSA1, BAG3, CACYBP, CCT3, DNAJA1, HSP90AA1, HSP90AB1, HSPA8 +4 more	View in SCUBA
Endothelial	Heat Shock Response Stress	BAG3, DNAJA1, DNAJA4, HSPA8, HSPD1, HSPE1, HSPH1, IER5 +2 more	View in SCUBA
Gamma-delta T cells	ER/Osmotic Stress Stress	ABHD3, DNAJA4, FKBP4, HIBCH, HSD17B7, HSPA4, HSPB1, MBNL2 +7 more
Goblet cells	Heat Shock Response Stress	DNAJA1, EIF1AX, EIF5, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA8 +5 more	View in SCUBA
Innate lymphoid cells	Heat Shock Response Stress	AHSA1, ANKRD37, DEDD2, DNAJB1, DNAJB4, HSP90AA1, HSP90AB1, HSPA1A +9 more	View in SCUBA
Monocytes	Heat Shock Response Stress	CHORDC1, DNAJA1, DNAJB1, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA8 +4 more	View in SCUBA
Mucosal-associated invariant T cell	Heat Shock Response Stress	AHSA1, BAG3, CACYBP, CAPG, CHORDC1, CSF1, DNAJA4, DNAJB4 +13 more
Natural Killer cells	Heat Shock Response Stress	AHSA1, ANKRD37, CACYBP, CHORDC1, HSP90AA1, HSP90AB1, HSPA8, HSPD1 +3 more	View in SCUBA
Pericytes	Proteostasis Quality Control Housekeeping	DNAJB6, GNAI3, HNRNPF, HSP90AB1, HSPE1, MAP1LC3B, UBE2D3	View in SCUBA

About the gene

Synonyms	HSPC071
Chromosome	6: 159789812-159798436
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Ribosomal proteins
Molecular function	Chaperone, Ribonucleoprotein, Ribosomal protein, RNA-binding
Biological process	Transport

Function

Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.