BMP-Stromal Signaling
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes: BMP4 (bone morphogenetic protein, developmental/stromal signaling), PDGFRA (PDGF receptor alpha, canonical fibroblast/stromal marker), CXCL14 (stromal chemokine), TMEM176A/B (transmembrane proteins expressed in stromal/myeloid cells), POSTN (periostin, fibroblast/ECM), MMP2 (matrix metalloproteinase-2, ECM remodeling), F3 (tissue factor/coagulation), NBL1 (DAN family BMP antagonist). The combination of BMP4, NBL1 (BMP antagonist), PDGFRA, POSTN, and MMP2 points to a fibroblast/stromal subpopulation with active BMP signaling and ECM remodeling. PDGFRA is a defining marker of fibroblasts/stromal cells. The moderate coherence and mixed membership scores suggest this may blend a fibroblast identity program with BMP pathway activity. Upregulated in remission (CD 0.402), consistent with stromal restoration. Neighbor to M59 and M36 supports stromal/mesenchymal context.
Genes
BMP4, CXCL14, F3, MMP2, NBL1, PDGFRA, POSTN, TMEM176A, TMEM176B
Most correlated modules
- Stromal ECM Production · correlation 0.73
- Pericyte Identity · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.