Pericyte Identity
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes FOXF1 (forkhead transcription factor critical for mesenchymal/pericyte identity), TCF21 (mesenchymal transcription factor), NR2F1 (nuclear receptor in vascular/mesenchymal development), LRP1 (endocytic receptor on pericytes/fibroblasts), EDIL3 (EGF-like domain ECM protein), LTBP4 (latent TGF-beta binding protein), PTCH1 (Hedgehog pathway receptor), MXRA5 (matrix remodeling), EMID1 (EMI domain ECM), and ADAMDEC1 collectively define a pericyte/stromal identity program. FOXF1 and TCF21 are canonical pericyte/mesenchymal transcription factors. The module is uniformly expressed, strongly coherent, and not disease-responsive, consistent with a constitutive cell identity program rather than a reactive state. Neighbor context: sits near ECM-producing modules (M36, M43), supporting a mesenchymal identity theme.
Genes
ADAMDEC1, EDIL3, EMID1, FOXF1, IL1R1, LRP1, LTBP4, MXRA5, NR2F1, PTCH1, TCF21
Most correlated modules
- Stromal ECM Production · correlation 0.69
- BMP-Stromal Signaling · correlation 0.68
- Fibrotic ECM Remodeling · correlation 0.58
- Pericyte ECM Secretion · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.