POSTN — Periostin
POSTN belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
POSTN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Wnt Angiogenic Remodeling ECM remodeling | ADAMTS4, ADGRL2, BAZ1A, FKBP11, IL4R, LDLRAD3, LEF1, MTHFD2 +5 more | View in SCUBA |
| Fibroblasts | Myofibroblast Subtype Wound healing | EDNRB, FOXL1, HACD4, KCTD9, MGLL, PDGFD, TSPAN33, ZEB1 | View in SCUBA |
| Pericytes | BMP-Stromal Signaling Developmental | BMP4, CXCL14, F3, MMP2, NBL1, PDGFRA, TMEM176A, TMEM176B | View in SCUBA |
| Smooth muscle cells | Synthetic Matrix Phenotype ECM remodeling | APOE, CFD, GAS6, GJA1, MAP1LC3A, MXRA5, PHF14, PLAU +1 more | View in SCUBA |
About the gene
| Synonyms | OSF-2, periostin, PN |
|---|---|
| Chromosome | 13: 37562583-37598844 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Heparin-binding |
| Biological process | Cell adhesion |
Function
Induces cell attachment and spreading and plays a role in cell adhesion. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.