Nuclear Export Replication
Gene co-expression module in Plasma cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 36 genes have a known function matching the annotation |
Why this annotation
Moderate coherence, plasmablast-enriched, significantly increased with inflammation. Hub genes include CSE1L (CAS/chromosome segregation 1-like, nuclear export of importin-alpha), TPR (nuclear pore basket, mRNA export), NUP-associated export machinery, RFC1 (DNA replication clamp loader), RCC2 (regulator of chromosome condensation 2, mitosis), ROCK1 (Rho-associated kinase, cytoskeletal/mitosis), RBM25 and SF3B1 (splicing), RBM28 (ribosome biogenesis), ITGB2 (integrin beta-2, adhesion), RABL6 (Rab GTPase, cell cycle). The nuclear export theme (CSE1L, TPR) combined with DNA replication (RFC1) and chromosome organization (RCC2) in proliferating plasmablasts is the dominant signal. Neighbor to M6 (RNA splicing), together supporting a proliferating plasmablast transcriptional program.
Genes
Most correlated modules
- Plasmablast Stress Activation · correlation 0.97
- Polyamine Biosynthesis · correlation 0.97
- Nuclear Transport Chromatin · correlation 0.97
- Plasmablast Apoptosis · correlation 0.97
- Plasmablast Proliferation · correlation 0.96
- RNA Splicing Processing · correlation 0.95
- COPI Vesicle Trafficking · correlation 0.95
- Plasmablast Trafficking · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.