Polyamine Biosynthesis
Gene co-expression module in Plasma cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub ATP13A3 is a P5-type ATPase that transports polyamines and is strongly upregulated in activated/proliferating cells. SMS (spermine synthase) catalyzes the final step of spermine biosynthesis. Together these define a polyamine biosynthesis/transport program. UBN1 and RBBP7 are subunits of the HIRA histone chaperone complex involved in replication-independent chromatin assembly. BARD1 (BRCA1-associated) and RIF1 are DNA damage response/repair factors. ADAR performs adenosine-to-inosine RNA editing, upregulated in activated immune cells. RHOG and ARHGAP30 are Rho GTPase signaling components. WDR1 promotes actin dynamics. The module is strongly upregulated with inflammation and enriched in plasmablasts. The dominant biological theme is polyamine metabolism supporting rapid plasmablast proliferation and activation, with co-regulated chromatin and DNA repair programs.
Genes
Most correlated modules
- Nuclear Export Replication · correlation 0.97
- Nuclear Transport Chromatin · correlation 0.96
- Plasmablast Stress Activation · correlation 0.95
- Plasmablast Apoptosis · correlation 0.95
- Plasmablast Trafficking · correlation 0.95
- Plasmablast Proliferation · correlation 0.94
- N-glycosylation ER · correlation 0.93
- Plasmablast Differentiation · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.