Oxidative Phosphorylation
Gene co-expression module in Plasma cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
All top hub genes are core components of the mitochondrial electron transport chain (NDUFV2, NDUFB8: Complex I; UQCR10: Complex III; COX6A1: Complex IV; ATP5MC3, ATP5MF: Complex V/ATP synthase) and TCA cycle (MDH2), with CHCHD2 in the mitochondrial intermembrane space. PSMA7 (proteasome) is a minor outlier but co-regulated. Strong coherence and consistent plasmablast enrichment (3-5x). The strong UC inflammation association reflects plasmablast expansion. This is a tight oxidative phosphorylation module.
Genes
Most correlated modules
- OxPhos & Proteasome · correlation 0.98
- Oxidative Phosphorylation · correlation 0.98
- Mitochondrial Respiration · correlation 0.98
- Proteasome Activity · correlation 0.97
- Glycolytic Reprogramming · correlation 0.97
- Protein Quality Control · correlation 0.97
- Ubiquitin-like Modification · correlation 0.97
- Spliceosome snRNP Assembly · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.