OxPhos & Proteasome
Gene co-expression module in Plasma cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 17 genes have a known function matching the annotation |
Why this annotation
Top hub genes include ATP5MC1, COX6B1, COX5B, COX6C (mitochondrial respiratory chain Complex IV/V), AURKAIP1 (mitochondrial), MRPL51 (mitoribosome), PRELID1 (mitochondrial lipid transfer), CHCHD10 (mitochondrial cristae). Also contains PSMB6/PSME2/PSMD8 (proteasome subunits), RBX1/ANAPC11 (ubiquitin E3 ligase components), COPE (COPI vesicle coat), SRP9 (signal recognition particle). The module is significantly upregulated with inflammation (sig. in UC). The dominant program is OxPhos/mitochondrial combined with proteasomal protein degradation — both reflecting the high energy and protein turnover demands of activated plasmablasts. Neighbor M28 is a purer OxPhos module; M2 adds proteasome/ubiquitin components.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.98
- Mitochondrial Respiration · correlation 0.98
- Oxidative Phosphorylation · correlation 0.97
- hnRNP RNA Processing · correlation 0.97
- Oxidative Phosphorylation · correlation 0.97
- Proteasome Activity · correlation 0.97
- Protein Quality Control · correlation 0.97
- Glycolytic Reprogramming · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.