Mitochondrial Respiration
Gene co-expression module in Plasma cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes include UQCRH (Complex III ubiquinol-cytochrome c reductase hinge), NDUFS5 (Complex I NADH dehydrogenase), COX8A and COX7B (Complex IV cytochrome c oxidase subunits), ATP5PO (ATP synthase), SLC25A5 (ANT2, mitochondrial ADP/ATP translocator), MDH1 (malate dehydrogenase, TCA cycle). Glycolytic enzymes GAPDH and LDHB are also prominent hubs. PSMB2/PSMB3 (proteasome) and PFN1 (profilin, actin) are additional components. CALM3 (calmodulin) and RAC2 (Rho GTPase) add signaling. The mitochondrial respiratory chain genes (Complexes I, III, IV, V) are the most coherent cluster, with glycolysis co-regulated. PARK7 (DJ-1) is a mitochondrial oxidative stress sensor. NOP10 is a ribosome biogenesis factor. The dominant program is mitochondrial electron transport chain activity, distinguishable from M50 by emphasis on Complex III/IV over ATP synthase.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.98
- OxPhos & Proteasome · correlation 0.98
- Oxidative Phosphorylation · correlation 0.98
- Proteasome Activity · correlation 0.98
- Protein Quality Control · correlation 0.97
- RNA Splicing & Glycolysis · correlation 0.97
- Ubiquitin-like Modification · correlation 0.97
- Spliceosome snRNP Assembly · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.