Proteasome Activity
Gene co-expression module in Plasma cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 25 genes have a known function matching the annotation |
Why this annotation
Top hub genes are proteasome subunits (PSMC5, PSMB7, PSMD2) alongside metabolic genes (PGK1 glycolysis, VDAC1/TIMM10 mitochondrial import, GLRX5 iron-sulfur, ATP5PB/NDUFB3 OxPhos), RNA processing (LSM4, ALYREF, HNRNPF), and ubiquitin pathway (UBE2N). The proteasome subunits dominate by PageRank and are the clearest functional anchor. In the plasmablast context, high proteasome activity is essential for immunoglobulin quality control and ER-associated degradation. The metabolic and RNA processing genes likely reflect the broader biosynthetic demand co-regulated with proteasome activity. Neighbor modules M53 and M50 also contain proteasome subunits, confirming a shared protein homeostasis neighborhood. The module is enriched in inflammation and reduced by treatment, consistent with active plasmablast expansion.
Genes
Most correlated modules
- Glycolytic Reprogramming · correlation 0.98
- RNA Splicing & Glycolysis · correlation 0.98
- Spliceosome snRNP Assembly · correlation 0.98
- Protein Quality Control · correlation 0.98
- Mitochondrial Respiration · correlation 0.98
- Chaperonin Protein Folding · correlation 0.98
- hnRNP RNA Processing · correlation 0.97
- Actin Cytoskeletal Dynamics · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.